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KMID : 0604520200460010043
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Journal of the Society of Cosmetic Scientists of Korea
2020 Volume.46 No. 1 p.43 ~ p.47
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Adamantyl-based N-arylamide as a Novel Series of Androgen Receptor Antagonists
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Woo Byoung-Young
Shin Song-Seok
Hong Yong-Deog
Joo Yung-Hyup
Jeong Yeon-Su
Lee Beom-Jin
Kim Soo-Dong
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Abstract
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A novel series of adamantyl derivatives of N-aryl amides as androgen receptor antagonists were synthesized and their anti-androgenic activities were evaluated. The N-aryl amides containing adamantyl derivatives had more activity than those lacking adamantyl substitutions. The synergistic effect of bulkiness of the adamantyl group and modulation of electron density on the aromatic ring by pendant groups was crucial to the potent antagonism. Molecular modeling studies were performed to elucidate the interactions between ligands and receptors.
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KEYWORD
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androgen receptor, admantyl N-aryl amide, hair loss
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